Effectiveness of SARS-CoV-2 Vaccines for Short- and Long-Term Immunity: A General Overview for the Pandemic Contrast단기 및 장기 면역을 위한 SARS-CoV-2 백신의 효과: 유행병 대비에 대한 일반 개요Review Published on 2022-07-302022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] ACE2 anchor Anti-spike antibodies bind booster Cell cell receptor Comorbidity concerning Contrast COVID-19 COVID-19 disease COVID-19 pandemic dentistry diagnoses disease disease severity Efficiency enzyme evaluate flu Golgi apparatus Host immunization Infection Interaction knowledge mechanism MERS mortality rate observance pandemic Patient Pfizer Primary prevention produced Protein Protein target protocol provide question reduction in Release released RNA SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 variant SARS-CoV-2 variants severity significant increase spike Spike protein Spike proteins the cells the disease the SARS-CoV-2 Therapies therapy TMPRSS2 Treatment protocol treatment protocols Vaccine Vaccines Vaccines. Viral viral infection virion virus virus viruses [DOI] 10.3390/ijms23158485 PMC 바로가기 [Article Type] Review
Status of Humoral and Cellular Immune Responses within 12 Months following CoronaVac Vaccination against COVID-19COVID-19에 대한 CoronaVac 백신 접종 후 12개월 이내에 체액 및 세포 면역 반응의 상태Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] 12 months addition antibody approved baseline binding binding and neutralizing antibodies binding antibodies binding antibody CD4 CD8 Cell Cellular immune response cellular response Cellular responses central memory CoronaVac country COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines Critical declined detectable dose effector memory Emergency use Endpoint enrolled Evidence functional gamma interferon granzyme B GzmB humoral Humoral and cellular immune responses IFN-γ IL-2 IL-5 immune memory immune persistence immune responses Inactivated vaccine interleukin interleukin 2 memory T cell memory T cells Month Neutralizing antibodies neutralizing antibody neutralizing antibody responses neutralizing antibody. participant persistence produced provide RBD Receptor-binding domain reported response SARS-CoV-2 SARS-CoV-2 RBD second dose secretion seroconversion rate seropositive significantly higher status Stimulation T cells the cells the receptor-binding domain understanding vaccination vaccination schedule Vaccination strategy Vaccine [DOI] 10.1128/mbio.00181-22 PMC 바로가기 [Article Type] Article
Anti-nucleocapsid antibodies enhance the production of IL-6 induced by SARS-CoV-2 N protein항-뉴클레오캡시드 항체는 SARS-CoV-2 N 단백질에 의해 유도된 IL-6의 생산을 향상시킵니다Article Published on 2022-05-162022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료법, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibody cause of death cell lysate coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cultured macrophage cultured macrophages cytokine cytokine production Cytokine storm death disease ENhance IL-6 induce infected cells interleukin lysate macrophages mechanism myeloid cells N protein Patient patients Plasmid promote respiratory respiratory distress SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2-infected cell SARS-CoV-2-infected cells Screening secreted sera severe acute respiratory syndrome Coronavirus syndrome the cell the cells the cytokine storm the disease [DOI] 10.1038/s41598-022-12252-y PMC 바로가기 [Article Type] Article
Post-mortem Findings of Inflammatory Cells and the Association of 4-Hydroxynonenal with Systemic Vascular and Oxidative Stress in Lethal COVID-19 †염증 세포의 부검 결과 및 치명적인 코로나19에서 4-하이드록시노넨알과 전신 혈관 및 산화 스트레스의 연관성 †Article Published on 2022-01-272022-09-11 Journal: Cells [Category] 바이오마커, 진단, [키워드] 4-hydroxynonenal 4-hydroxynonenal (4-HNE) absence acute tubular necrosis affected alveolar damage analyzed astrocytes Autopsy Biomarker Biomarkers blood vessel blood vessels Brain cells COVID-19 detrimental died differential expression Diffuse alveolar damage dismutase edema edematous finding Granulocytes immune system immunohistochemical analysis Infection inflammatory cell inflammatory cells inflammatory parameters kidneys lethal leukocyte lipid peroxidation lung Lungs mitochondrial MPO myeloperoxidase nine organ organs oxidative burst oxidative stress Patient reactive reactive oxygen species (ROS) SAR-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Sepsis SOD2 Stress suggested Superoxide Superoxide Dismutase superoxide dismutase (SOD) survivor systemic the cells tissue Tubular Necrosis Vascular vascular stress [DOI] 10.3390/cells11030444 PMC 바로가기 [Article Type] Article
Kite-Shaped Molecules Block SARS-CoV-2 Cell Entry at a Post-Attachment Step연 자형 분자는 상착 후 단계에서 SARS-COV-2 세포 진입을 차단합니다.Article Published on 2021-11-192022-09-10 Journal: Viruses [Category] MERS, SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-viral activity anti-viral screening Antiviral block cells Compound compounds coronavirus Coronavirus infection Coronavirus-2 COVID-19 demonstrated drug drugs human cell lines Infection inhibitory activity kidney moderate molecule not affect Outbreaks pharmacophore Prevent pseudovirus respiratory SARS-CoV-1 SARS-CoV-2 Screen screened small molecule Small molecules Spike protein step structural homology the cells Viral virus virus attachment virus entry virus post-attachment [DOI] 10.3390/v13112306 PMC 바로가기 [Article Type] Article
Supplying the trip to antibody production—nutrients, signaling, and the programming of cellular metabolism in the mature B lineage항체 생산으로의 이동 - 영양소, 신호 전달, 성숙한 B 계통의 세포 대사 프로그래밍 제공Review Published on 2021-11-152022-09-11 Journal: Cellular and Molecular Immunology [Category] Fulltext, MERS, 유전자 메커니즘, 진단, [키워드] antibody B lymphocyte Cell cell surface receptor cell surface receptors cell type cell types cellular cellular metabolism COVID cytokine Cytokines elicit enzyme exhibiting Fatty acid focus gene transcription Germinal centres Glucose Glutamine Glycoproteins immune defense Infection Intermediary metabolism interstitium lead Lineage Lymphocytes mechanism metabolism microbe microbes microenvironment molecular nutrient pandemic Plasma cell Plasma cells plasmablast plasmablasts programming proliferate receive Recognition regulate secrete secreted secreting secretion Signal transduction Signaling Somatic hypermutation Stage sustained the cells Transcription translation turn Vaccine [DOI] 10.1038/s41423-021-00782-w PMC 바로가기 [Article Type] Review
mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection statusmRNA 백신 유도 T 세포는 우려되는 SARS-CoV-2 변이체에 동일하게 반응하지만 이전 감염 상태에 따라 수명과 귀환 특성이 다릅니다.Research Article Published on 2021-10-122022-09-10 Journal: eLife [Category] MERS, SARS, 변종, [키워드] activate activated Analysis antibodies antibody Antigen-specific T cells B.1.1.7 B.1.351 B.1.351 variant best boost immunity booster dose both groups caused Cell changed Characteristics conducted convalescent coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 convalescent donor COVID-19 convalescent donors CyTOF Cytometry determine dose doses elicit Epitopes Examining flight Focusing generate highlight homing Human identity Immune cell immune cells immune defense immune response immune system IMPROVE individuals Infection investigated killing longitudinal study Lungs Lymphocyte subsets mimicking MOST mRNA mRNA vaccine mRNA vaccines naïve vaccinees nasopharynx natural infection nose not need offer persistence phenotype Phenotypes phenotypic phenotypic feature phenotypic features Prevent PROTECT Protein Proteins quantity reassurance recognizing Research researcher respiratory tract respond SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells second dose severe COVID-19 spike epitope spike epitopes spike-specific T cell Stimulation Strains surface protein surface proteins T cell T cell response T cells the cells the vaccine These cells two group two groups unique vaccination Vaccine vaccine dose vaccine doses vaccine-elicited T cell vaccinee vaccinees variant variants Viral Viral variants virus viruses while [DOI] 10.7554/eLife.72619 PMC 바로가기 [Article Type] Research Article
Natto extract, a Japanese fermented soybean food, directly inhibits viral infections including SARS-CoV-2 in vitro일본 발효 대두 음식 인 Natto 추출물은 시험 관내 SARS-COV-2를 포함한 바이러스 감염을 직접 억제합니다.Article Published on 2021-09-172022-08-31 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis Antiviral effect Bacillus Bacillus subtilis BHV-1 binding bovine caused Cell cells coronavirus domain Evidence examined glycoprotein Glycoprotein D Health heat inactivation impair in vitro incubated infect Infection inhibit inhibited Japanese N501Y Natto nutritious Point mutation protease proteolysis RBD RBD protein Receptor binding domain respiratory restored SARS-CoV-2 SARS-CoV-2. Serine serine protease inhibitor severe acute respiratory syndrome Coronavirus shown the cells treated variant Viral viral infection Viral proteins viruses western blot Western blot analysis [DOI] 10.1016/j.bbrc.2021.07.034 PMC 바로가기 [Article Type] Article
Direct detection of SARS-CoV-2 antisense and sense genomic RNA in human saliva by semi-autonomous fluorescence in situ hybridization: A proxy for contagiousness?반자동 형광에서 인간 타액에서 SARS-COV-2 안티센스 및 감각 게놈 RNA의 직접 검출 : 현장 하이브리드 화 : 전염성을위한 대리?Research Article Published on 2021-08-172022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] addition All participants antisense applied Cell collected contagiousness cytological described diagnostic Direct DNA Fluorescence genomic genomic RNA healthy human saliva In situ hybridization information interpretability matrix Mild moderate Moderate COVID-19 Participants pathogen transmission pilot study positive presenting probe probes provide Saliva saliva samples SARS-CoV-2 SARS-CoV-2 RNA sense Symptoms test results tested the cells the healthy Validity vector Viral Viral load viral replication virus Visualization [DOI] 10.1371/journal.pone.0256378 PMC 바로가기 [Article Type] Research Article
Severe Acute Respiratory Syndrome Coronavirus-2 Inactivation Activity of the Polyphenol-Rich Tea Leaf Extract with Concentrated Theaflavins and Other Virucidal Catechins중증 급성 호흡기 증후군 코로나바이러스-2 농축 테아플라빈 및 기타 바이러스성 카테킨을 함유한 폴리페놀이 풍부한 찻잎 추출물의 불활성화 활성Article Published on 2021-08-082022-09-10 Journal: Molecules [Category] MERS, SARS, 치료제, [키워드] absence activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed auxiliary catechin Cell Cell culture cell culture medium cells coronavirus culture media culture medium death ENhance evaluate evaluated Extract Genome Impact in vitro incubated Incubation Infection inhibited inhibition activity leaf Measures media Other polyphenol producing provided real-time RT-PCR replaced respiratory RT-PCR S protein S2 subunit SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus structural protein structural proteins suggested tea tea leaf extract the cell the cells the S protein theaflavin Treatment Ty-1 Viral viral genome Viral protein Viral proteins Viral RNA viral titer viral titers virucidal virucidal activity western blotting [DOI] 10.3390/molecules26164803 PMC 바로가기 [Article Type] Article